“The regenerative medicine revolution is upon us. Like iron and steel to the industrial revolution, like the microchip to the tech revolution, stem cells will be the driving force of this next revolution.”
Cade Hildreth, founder of BioInformant, a stem cell industry research firm. Citado por: Tony Robbins,
Peter Diamandis and Robert Hariri. Life Force; Simon and Schuster, 2022.

“Stem cells seem to hold major promise for contemporary medicine, one which could almost be more significant than a discovery of DNA”
Kurpisz M. New Technologies Based on Stem Cell-Therapies in Regenerative Medicine and Reproductive
Biology. Cells. 2022 Dec 26;12(1):95.

OSTEOARTHRITIS

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    Rotator Cuff Repair: A Systematic Review of Data From 2010 to 2022.
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    Mesenchymal Stem Cells in the Treatment of Chronic Low Back Pain Due
    to Severe Lumbar Spinal Degeneration: A 12-Month, Open-Label,
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CARDIOVASCULAR DISEASES


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    of Adipose-Derived Stromal Cells Assessed by Cardiac Magnetic
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    myocardial infarction: roles of mesenchymal stem cells and their
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    stem cell therapy in patients with acute myocardial infarction: a
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    10.1186/s13287-021-02667-1.
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    First-in-human pilot trial of combined intracoronary and intravenous
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    cardiovascular events after bone marrow mononuclear cell
    transplantation following acute myocardial infarction: an updated
    post-BAMI meta-analysis of randomized controlled trials. BMC
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    bone marrow mono-nuclear cells with mesenchymal stem cells after
    acute myocardial infarction on improvement of left ventricular function: a
    meta-analysis of clinical trials. Stem Cell Res Ther. 2022;13(1):203. doi:
    10.1186/s13287-022-02883-3.
  • Davidson SJ, Roncalli J, Surder D, Corti R, Chugh AR, Yang PC, et al.
    Microvascular Obstruction Identifies a Subgroup of Patients Who Benefit
    from Stem Cell Therapy Following ST-Elevation Myocardial Infarction. Am
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  • Gil H, Goldshtein M, Etzion S, Elyagon S, Hadad U, Etzion Y, Cohen S.
    Defining the timeline of periostin upregulation in cardiac fibrosis following
    acute myocardial infarction in mice. Sci Rep. 2022;12(1):21863. doi:
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  • Tripathi A, Khan MS, Khan AR, Vaughn VM, Bolli R. Cell therapy for
    nonischemic dilated cardiomyopathy: A systematic review and
    meta-analysis of randomized controlled trials. Stem Cells Transl Med.
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    Heart Failure: A Comprehensive Review and Emerging Concepts.
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    Stem Cell Therapy as a Novel Treatment of Heart Failure with Preserved
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    Clinical Outcomes in Patients With Heart Failure. Cureus.
    2021;13(8):e17236. doi: 10.7759/cureus.17236.
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    10.1002/14651858.CD013433.pub2.
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    administration routes for heart failure: a comparative re-evaluation of the
    REGENERATE-DCM and REGENERATE-IHD trials. Regen Med. 2022. doi:
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    et al. Meta-Analysis of Percutaneous Endomyocardial Cell Therapy in
    Patients with Ischemic Heart Failure by Combination of Individual Patient
    Data (IPD) of ACCRUE and Publication-Based Aggregate Data. J Clin Med.
    2022;11(11):3205. doi: 10.3390/jcm11113205.
  • Bolli R, Tang XL. The sad plight of cell therapy for heart failure: causes
    and consequences. J Cardiovasc Aging. 2022;2:16. doi:
    10.20517/jca.2022.02.
  • Bolli R, Solankhi M, Tang XL, Kahlon A. Cell therapy in patients with
    heart failure: a comprehensive review and emerging concepts. Cardiovasc
    Res. 2022;118(4):951-976. doi: 10.1093/cvr/cvab135.
  • Ogay V, Sekenova A, Li Y, Issabekova A, Saparov A. The Therapeutic
    Potential of Mesenchymal Stem Cells in the Treatment of Atherosclerosis.
    Curr Stem Cell Res Ther. 2021. doi:
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    new therapeutic target to atherosclerosis treatment. Mol Cell Biochem.
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    Properties and fate of human mesenchymal stem cells upon miRNA
    let-7f-promoted recruitment to atherosclerotic plaques. Cardiovasc Res.
    2022:cvac022. doi: 10.1093/cvr/cvac022.
  • Sharma S, Pandey NN, Sinha M, Kumar S, Jagia P, Gulati GS, et al.
    Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate Safety
    and Therapeutic Efficacy of Angiogenesis Induced by Intraarterial
    Autologous Bone Marrow-Derived Stem Cells in Patients with Severe
    Peripheral Arterial Disease. J Vasc Interv Radiol. 2021;32(2):157-163. doi:
    10.1016/j.jvir.2020.09.003.
  • Gupta PK, Dutta S, Kala S, Nekkanti M, Desai SC, Mahapatra SS, et al.
    Phase IV postmarketing surveillance study shows continued efficacy and
    safety of Stempeucel in patients with critical limb ischemia due to
    Buerger’s disease. Stem Cells Transl Med. 2021;10(12):1602-1613. doi:
    10.1002/sctm.21-0197.

PULMONARY DISEASES


  • van Geffen C, Deißler A, Quante M, Renz H, Hartl D, Kolahian S.
    Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or
    Foes? Front Immunol. 2021;12:663203. doi:
    10.3389/fimmu.2021.663203.
  • Chen Y, Liu X, Tong Z. Mesenchymal Stem Cells in Radiation-Induced
    Pulmonary Fibrosis: Future Prospects. Cells. 2022;12(1):6. doi:
    10.3390/cells12010006.
  • Zhang T, Zhang J, Lv C, Li H, Song X. Senescent AECⅡ and the implication
    for idiopathic pulmonary fibrosis treatment. Front Pharmacol.
    2022;13:1059434. doi: 10.3389/fphar.2022.1059434.
  • Kletukhina S, Mutallapova G, Titova A, Gomzikova M. Role of
    Mesenchymal Stem Cells and Extracellular Vesicles in Idiopathic
    Pulmonary Fibrosis. Int J Mol Sci. 2022;23(19):11212. doi:
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    fibrosis. Stem Cell Res Ther. 2022;13(1):492. doi:
    10.1186/s13287-022-03181-8.
  • Saleh M, Fotook Kiaei SZ, Kavianpour M. Application of Wharton
    jelly-derived mesenchymal stem cells in patients with pulmonary fibrosis.
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  • Sun QW, Sun Z. Stem cell therapy for pulmonary arterial hypertension:
    An update. J Heart Lung Transplant. 2022:S1053-2498(22)01847-2. doi:
    10.1016/j.healun.2022.02.020.
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    et al. Autologous Infusion of Bone Marrow and Mesenchymal Stromal
    Cells in Patients with Chronic Obstructive Pulmonary Disease: Phase I
    Randomized Clinical Trial. Int J Chron Obstruct Pulmon Dis.
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  • Wang X, Zhao Y, Li D, Feng Y, Xie Y, et al. Intrapulmonary distal airway
    stem cell transplantation repairs lung injury in chronic obstructive
    pulmonary disease. Cell Prolif. 2021:e13046. doi: 10.1111/cpr.13046.
  • Cereta AD, Oliveira VR, Costa IP, Afonso JPR, Fonseca AL, de Souza
    ART, et al. Emerging Cell-Based Therapies in Chronic Lung Diseases: What
    About Asthma? Front Pharmacol. 2021;12:648506. doi:
    10.3389/fphar.2021.648506.
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    obstructive pulmonary disease. Chin Med J (Engl).
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    of circulating mononuclear cells from patients with chronic obstructive
    pulmonary disease receiving mesenchymal stromal cell infusions. Stem
    Cells Transl Med. 2021. doi: 10.1002/sctm.21-0024.
  • Abbaszadeh H, Ghorbani F, Abbaspour-Aghdam S, Kamrani A,
    Valizadeh H, Nadiri M, et al. Chronic obstructive pulmonary disease and
    asthma: mesenchymal stem cells and their extracellular vesicles as
    potential therapeutic tools. Stem Cell Res Ther. 2022;13(1):262. doi:
    10.1186/s13287-022-02938-5.
  • Calzetta L, Aiello M, Frizzelli A, Camardelli F, Cazzola M, Rogliani P,
    Chetta A. Stem Cell-Based Regenerative Therapy and Derived Products in
    COPD: A Systematic Review and Meta-Analysis. Cells. 2022;11(11):1797.
    doi: 10.3390/cells11111797.

LIVER DISEASES


  • Ma JF, Gao JP, Shao ZW. Acute liver failure: A systematic review and network
    meta-analysis of optimal type of stem cells in animal models. World J Stem Cells.
    2023;15(1):1-15. doi: 10.4252/wjsc.v15.i1.1.
  • Sun H, Shi C, Ye Z, Yao B, Li C, Wang X, Qian Q. The role of mesenchymal stem cells
    in liver injury. Cell Biol Int. 2021. doi: 10.1002/cbin.11725.
  • Shi M, Li YY, Xu RN, Meng FP, Yu SJ, Fu JL, et al. Mesenchymal stem cell therapy
    in decompensated liver cirrhosis: a long-term follow-up analysis of the randomized
    controlled clinical trial. Hepatol Int. 2021. doi: 10.1007/s12072-021-10199-2.
  • Schacher FC, Martins Pezzi da Silva A, Silla LMDR, Álvares-da-Silva MR. Bone
    Marrow Mesenchymal Stem Cells in Acute-on-Chronic Liver Failure Grades 2 and 3:
    A Phase I-II Randomized Clinical Trial. Can J Gastroenterol Hepatol.
    2021;2021:3662776. doi: 10.1155/2021/3662776.
  • Zhu CH, Zhang DH, Zhu CW, Xu J, Guo CL, Wu XG, et al. Adult stem cell
    transplantation combined with conventional therapy for the treatment of
    end-stage liver disease: a systematic review and meta-analysis. Stem Cell Res Ther.
    2021;12(1):558. doi: 10.1186/s13287-021-02625-x.
  • Han J, Lee C, Hur J, Jung Y. Current Therapeutic Options and Potential of
    Mesenchymal Stem Cell Therapy for Alcoholic Liver Disease. Cells. 2022;12(1):22.
    doi: 10.3390/cells12010022.
  • Cheng F, Huang Z, Wei W, Li Z. Mesenchymal Stem Cell Transplantation for
    hepatitis B virus-related acute-on-chronic liver failure:A systematic review and
    meta-analysis. Curr Stem Cell Res Ther. 2022. doi:
    10.2174/1574888X18666221214123844.
  • Gao Y, Yin X, Ren X. Advance of Mesenchymal Stem Cells in Chronic End-Stage
    Liver Disease Control. Stem Cells Int. 2022;2022:1526217. doi:
    10.1155/2022/1526217.
  • Li TT, Wang ZR, Yao WQ, Linghu EQ, Wang FS, Shi L. Stem Cell Therapies for
    Chronic Liver Diseases: Progress and Challenges. Stem Cells Transl Med.
    2022:szac053. doi: 10.1093/stcltm/szac053.
  • Siapati EK, Roubelakis MG, Vassilopoulos G. Liver Regeneration by
    Hematopoietic Stem Cells: Have We Reached the End of the Road? Cells.
    2022;11(15):2312. doi: 10.3390/cells11152312.
  • Yao L, Hu X, Dai K, Yuan M, Liu P, Zhang Q, Jiang Y. Mesenchymal stromal cells:
    promising treatment for liver cirrhosis. Stem Cell Res Ther. 2022;13(1):308. doi:
    10.1186/s13287-022-03001-z.
  • Jangra A, Kothari A, Sarma P, Medhi B, Omar BJ, Kaushal K. Recent
    Advancements in Antifibrotic Therapies for Regression of Liver Fibrosis. Cells.
    2022;11(9):1500. doi: 10.3390/cells11091500.
  • Nikokiraki C, Psaraki A, Roubelakis MG. The Potential Clinical Use of
    Stem/Progenitor Cells and Organoids in Liver Diseases. Cells. 2022;11(9):1410. doi:
    10.3390/cells11091410.
  • Jindal A, Jagdish RK, Kumar A. Hepatic Regeneration in Cirrhosis. J Clin Exp
    Hepatol. 2022;12(2):603-616. doi: 10.1016/j.jceh.2021.08.029.
  • Yuan M, Hu X, Yao L, Jiang Y, Li L. Mesenchymal stem cell homing to improve
    therapeutic efficacy in liver disease. Stem Cell Res Ther. 2022;13(1):179. doi:
    10.1186/s13287-022-02858-4.
  • Sun X, Guo S. Effectiveness of cell- and colony stimulating factor-based therapy
    for liver cirrhosis: a network meta-analysis of randomized controlled trials.
    Cytotherapy. 2022:S1465-3249(22)00006-8. doi: 10.1016/j.jcyt.2021.11.006.
  • Liu Y, Dong Y, Wu X, Xu X, Niu J. The assessment of mesenchymal stem cells
    therapy in acute on chronic liver failure and chronic liver disease: a systematic
    review and meta-analysis of randomized controlled clinical trials. Stem Cell Res
    Ther. 2022;13(1):204. doi: 10.1186/s13287-022-02882-4.
  • Nandula SR, Nylen ES, Sen S. Novel Therapeutics in Nonalcoholic Fatty Liver
    Disease: A Focus on Adult Stem Cells. Metab Syndr Relat Disord. 2023. doi:
    10.1089/met.2022.0069.
  • Yi S, Cong Q, Zhu Y, Xu Q. Mechanisms of Action of Mesenchymal Stem Cells in
    Metabolic-Associated Fatty Liver Disease. Stem Cells Int. 2023;2023:3919002. doi:
    10.1155/2023/3919002.
  • Liu P, Qian Y, Liu X, Zhu X, Zhang X, Lv Y, et al. Immunomodulatory role of
    mesenchymal stem cell therapy in liver fibrosis. Front Immunol. 2023;13:1096402.
    doi: 10.3389/fimmu.2022.1096402.
  • Zahmatkesh E, Khoshdel Rad N, Hossein-Khannazer N, Mohamadnejad M,
    Gramignoli R, Najimi M, et al. Cell and cell-derivative-based therapy for liver
    diseases; current approaches and future promises. Expert Rev Gastroenterol
    Hepatol. 2023. doi: 10.1080/17474124.2023.2172398.
  • Yang X, Li Q, Liu W, Zong C, Wei L, Shi Y, Han Z. Mesenchymal stromal cells in
    hepatic fibrosis/cirrhosis: from pathogenesis to treatment. Cell Mol Immunol. 2023.
    doi: 10.1038/s41423-023-00983-5.
  • Wang YH, Chen EQ. Mesenchymal Stem Cell Therapy in Acute Liver Failure. Gut
    Liver. 2023. doi: 10.5009/gnl220417.
  • Luo L, Lai C, Feng T, Yao Y, Xue H, Xiang G, Luo L, Huang X. Umbilical cord
    blood-derived mesenchymal stem cells transplantation decreases incidence of liver
    cancer in end-stage liver disease patients (ESLD): a retrospective analysis over 5
    years. Am J Transl Res. 2022;14(8):5848-5858.
  • Li Z, Zhou X, Han L, Shi M, Xiao H, Lin M, et al. Human Umbilical Cord
    Blood-Derived Mesenchymal Stem Cell Transplantation for Patients with
    Decompensated Liver Cirrhosis. J Gastrointest Surg. 2023. doi:
    10.1007/s11605-022-05528-1.

INFLAMATORY BOWEL DISEASES


  • Cham B, Witting PK. Editorial Immunomodulatory effects of intestinal
    mesenchymal cells in the context of Inflammatory Bowel Disease. Acta
    Physiol (Oxf). 2021:e13721. doi: 10.1111/apha.13721.
  • Huldani H, Margiana R, Ahmad F, Opulencia MJC, Ansari MJ, Bokov DO,
    et al. Immunotherapy of inflammatory bowel disease (IBD) through
    mesenchymal stem cells. Int Immunopharmacol. 2022;107:108698. doi:
    10.1016/j.intimp.2022.108698.
  • Shi MY, Liu L, Yang FY. Strategies to improve the effect of mesenchymal
    stem cell therapy on inflammatory bowel disease. World J Stem Cells.
    2022;14(9):684-699. doi: 10.4252/wjsc.v14.i9.684.
  • Li A, Liu S, Li L, Yu M. Mesenchymal Stem Cells Versus Placebo for
    Perianal Fistulizing Crohn’s Disease: A Systemic Review and
    Meta-Analysis. Surg Innov. 2023:15533506231157167. doi:
    10.1177/15533506231157167.
  • Fathallah N, Akaffou M, Haouari MA, Spindler L, Alam A, Barré A, et al.
    Deep remission improves the quality of life of patients with Crohn’s
    disease and anoperineal fistula treated with darvadstrocel: results of a
    French pilot study. Tech Coloproctol. 2023. doi:
    10.1007/s10151-023-02765-7.
  • Grim C, Noble R, Uribe G, Khanipov K, Johnson P, Koltun WA, et al.
    Impairment of tissue resident mesenchymal stem cells in chronic
    ulcerative colitis and Crohn’s disease. J Crohns Colitis. 2021:jjab001. doi:
    10.1093/ecco-jcc/jjab001.
  • Włodarczyk M, Czerwinska K, Włodarczyk J, Fichna J, Dziki A, Dziki Ł.
    Current Overview on the Use of Mesenchymal Stem Cells for Perianal
    Fistula Treatment in Patients with Crohn’s Disease. Life (Basel).
    2021;11(11):1133. doi: 10.3390/life11111133.
  • Wang R, Yao Q, Chen W, Gao F, Li P, Wu J, et al. Stem cell therapy for
    Crohn’s disease: systematic review and meta-analysis of preclinical and
    clinical studies. Stem Cell Res Ther. 2021;12(1):463. doi:
    10.1186/s13287-021-02533-0.
  • Sheikholeslami A, Fazaeli H, Khoshandam M, Kalhor N, Eshaghhosseini
    SJ, Sheykhhasan M. Use of Mesenchymal Stem Cells in Crohn’s Disease
    and Perianal Fistulas: A Narrative Review. Curr Stem Cell Res Ther. 2021.
    doi: 10.2174/1574888X16666210916145717.
  • Che Z, Ye Z, Zhang X, Lin B, Yang W, Liang Y, Zeng J. Mesenchymal
    stem/stromal cells in the pathogenesis and regenerative therapy of
    inflammatory bowel diseases. Front Immunol. 2022;13:952071. doi:
    10.3389/fimmu.2022.952071.
  • Furukawa S, Mizushima T, Nakaya R, Shibata M, Yamaguchi T,
    Watanabe K, Futami K. Darvadstrocel for complex perianal fistulas in
    Japanese adults with Crohn’s disease: a phase 3 study. J Crohns Colitis.
    2022:jjac144. doi: 10.1093/ecco-jcc/jjac144.
  • Zhang HM, Yuan S, Meng H, Hou XT, Li J, Xue JC, et al. Stem Cell-Based
    Therapies for Inflammatory Bowel Disease. Int J Mol Sci.
    2022;23(15):8494. doi: 10.3390/ijms23158494.
  • Johnson S, Hoch JS, Halabi WJ, Ko J, Nolta J, Dave M. Mesenchymal
    Stem/Stromal Cell Therapy Is More Cost-Effective Than Fecal Diversion
    for Treatment of Perianal Crohn’s Disease Fistulas. Front Immunol.
    2022;13:859954. doi: 10.3389/fimmu.2022.859954.
  • Wetwittayakhlang P, Al Khoury A, Hahn GD, Lakatos PL. The Optimal
    Management of Fistulizing Crohn’s Disease: Evidence beyond
    Randomized Clinical Trials. J Clin Med. 2022;11(11):3045. doi:
    10.3390/jcm11113045.
  • Saadh MJ, Mikhailova MV, Rasoolzadegan S, Falaki M, Akhavanfar R,
    Gonzáles JLA, et al. Therapeutic potential of mesenchymal stem/stromal
    cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD)
    therapy. Eur J Med Res. 2023;28(1):47. doi:
    10.1186/s40001-023-01008-7.
  • Reenaers C, Gillard RP, Coimbra C, Gillard RM, Meunier P, Lechanteur
    C, et al. Clinical and MRI evolution after local injection of bone
    marrow-derived mesenchymal stem cells in perianal fistulae in Crohn’s
    disease: results from a prospective monocentric study. J Crohns Colitis.
  • doi: 10.1093/ecco-jcc/jjac192.
  • Ko JZ, Johnson S, Dave M. Efficacy and Safety of Mesenchymal
    Stem/Stromal Cell Therapy for Inflammatory Bowel Diseases: An
    Up-to-Date Systematic Review. Biomolecules. 2021;11(1):82. doi:
    10.3390/biom11010082.

METABOLIC SYNDROME AND

TYPE 1 AND 2 DIABETES MELLITUS


  • Ogay V, Sekenova A, Li Y, Issabekova A, Saparov A. The Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Atherosclerosis. Curr
    Stem Cell Res Ther. 2021. doi: 10.2174/1574888X16999210128193549.
  • Shamsuddin SA, Chan AML, Ng MH, Yazid MD, Law JX, Hj Idrus RB, et al. Stem cells as a potential therapy in managing various disorders of metabolic
    syndrome: a systematic review. Am J Transl Res. 2021;13(11):12217-12227.
  • Wang L, Gao T, Li Y, Xie Y, Zeng S, Tai C, et al. A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated
    administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells. Stem Cell Res Ther. 2022;13(1):259. doi:
    10.1186/s13287-022-02935-8.
  • Cruciani S, Delitala AP, Cossu ML, Ventura C, Maioli M. Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its
    Treatment. Int J Mol Sci. 2023;24(3):2310. doi: 10.3390/ijms24032310.
  • Paris F, Pizzuti V, Marrazzo P, Pession A, Alviano F, Bonsi L. Perinatal Stem Cell Therapy to Treat Type 1 Diabetes Mellitus: A Never-Say-Die Story of
    Differentiation and Immunomodulation. Int J Mol Sci. 2022;23(23):14597. doi: 10.3390/ijms232314597.
  • Wang L, Liu T, Liang R, Wang G, Liu Y, Zou J, et al. Mesenchymal stem cells ameliorate β cell dysfunction of human type 2 diabetic islets by reversing β
    cell dedifferentiation. EBioMedicine. 2020;51:102615. doi: 10.1016/j.ebiom.2019.102615.
  • Gao S, Zhang Y, Liang K, Bi R, Du Y. Mesenchymal Stem Cells (MSCs): A Novel Therapy for Type 2 Diabetes. Stem Cells Int. 2022;2022:8637493. doi:
    10.1155/2022/8637493.
  • Li Y, Wang F, Liang H, Tang D, Huang M, Zhao J, et al. Efficacy of mesenchymal stem cell transplantation therapy for type 1 and type 2 diabetes mellitus:
    a meta-analysis. Stem Cell Res Ther. 2021;12(1):273. doi: 10.1186/s13287-021-02342-5.
  • He J, Kong D, Yang Z, Guo R, Amponsah AE, Feng B, Zhang X, Zhang W, Liu A, Ma J, O’Brien T, Cui H. Clinical efficacy on glycemic control and safety of
    mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data. PLoS One. 2021;16(3):e0247662. doi:
    10.1371/journal.pone.0247662.
  • Mathur A, Taurin S, Alshammary S. The Safety and Efficacy of Mesenchymal Stem Cells in the Treatment of Type 2 Diabetes- A Literature Review.
    Diabetes Metab Syndr Obes. 2023;16:769-777. doi: 10.2147/DMSO.S392161.
  • Gomes A, Coelho P, Soares R, Costa R. Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic
    approach. Cell Tissue Res. 2021. doi: 10.1007/s00441-021-03461-4.
  • Lu J, Shen SM, Ling Q, Wang B, Li LR, Zhang W, et al. One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1
    diabetes: an open parallel controlled clinical study. Stem Cell Res Ther. 2021;12(1):340. doi: 10.1186/s13287-021-02417-3.
  • Huang Q, Huang Y, Liu J. Mesenchymal Stem Cells: An Excellent Candidate for the Treatment of Diabetes Mellitus. Int J Endocrinol.
    2021;2021:9938658. doi: 10.1155/2021/9938658.
  • Pastore I, Assi E, Ben Nasr M, Bolla AM, Maestroni A, Usuelli V, et al. Hematopoietic Stem Cells in Type 1 Diabetes. Front Immunol. 2021;12:694118.
    doi: 10.3389/fimmu.2021.694118.
  • Pires IGS, Silva E Souza JA, de Melo Bisneto AV, Passos XS, Carneiro CC. Clinical efficacy of stem-cell therapy on diabetes mellitus: A systematic review
    and meta-analysis. Transpl Immunol. 2022:101740. doi: 10.1016/j.trim.2022.101740.
  • Jayasinghe M, Prathiraja O, Perera PB, Jena R, Silva MS, Weerawarna PSH, et al The Role of Mesenchymal Stem Cells in the Treatment of Type 1
    Diabetes. Cureus. 2022;14(7):e27337. doi: 10.7759/cureus.27337.
  • Zhang W, Ling Q, Wang B, Wang K, Pang J, Lu J, et al. Comparison of therapeutic effects of mesenchymal stem cells from umbilical cord and bone
    marrow in the treatment of type 1 diabetes. Stem Cell Res Ther. 2022;13(1):406. doi: 10.1186/s13287-022-02974-1.
  • Izadi M, Sadr Hashemi Nejad A, Moazenchi M, Masoumi S, Rabbani A, Kompani Fet al. Mesenchymal stem cell transplantation in newly diagnosed
    type-1 diabetes patients: a phase I/II randomized placebo-controlled clinical trial. Stem Cell Res Ther. 2022;13(1):264. doi:
    10.1186/s13287-022-02941-w.
  • Zang L, Li Y, Hao H, Liu J, Cheng Y, Li B, et al. Efficacy and safety of umbilical cord-derived mesenchymal stem cells in Chinese adults with type 2
    diabetes: a single-center, double-blinded, randomized, placebo-controlled phase II trial. Stem Cell Res Ther. 2022;13(1):180. doi:
    10.1186/s13287-022-02848-6.
  • Wan XX, Zhang DY, Khan MA, Zheng SY, Hu XM, Zhang Q, et al. Stem Cell Transplantation in the Treatment of Type 1 Diabetes Mellitus: From Insulin
    Replacement to Beta-Cell Replacement. Front Endocrinol (Lausanne). 2022;13:859638. doi: 10.3389/fendo.2022.859638.
  • Wu Z, Xu X, Cai J, Chen J, Huang L, Wu W, et al. Prevention of chronic diabetic complications in type 1 diabetes by co-transplantation of umbilical cord
    mesenchymal stromal cells and autologous bone marrow: a pilot randomized controlled open-label clinical study with 8-year follow-up. Cytotherapy.
    2022:S1465-3249(21)00825-2. doi: 10.1016/j.jcyt.2021.09.015.

CHRONIC RENAL FAILURE


  • Thomas HY, Ford Versypt AN. Pathophysiology of mesangial expansion
    in diabetic nephropathy: mesangial structure, glomerular biomechanics,
    and biochemical signaling and regulation. J Biol Eng. 2022;16(1):19. doi:
    10.1186/s13036-022-00299-4.
  • Lin W, Li HY, Yang Q, Chen G, Lin S, Liao C, Zhou T. Administration of
    mesenchymal stem cells in diabetic kidney disease: a systematic review
    and meta-analysis. Stem Cell Res Ther. 2021;12(1):43. doi:
    10.1186/s13287-020-02108-5.
  • Wang WJ, Chen XM, Cai GY. Cellular senescence and the
    senescence-associated secretory phenotype: Potential therapeutic
    targets for renal fibrosis. Exp Gerontol. 2021:111403. doi:
    10.1016/j.exger.2021.111403.
  • Wong CY. Current advances of stem cell-based therapy for kidney
    diseases. World J Stem Cells. 2021;13(7):914-933. doi:
    10.4252/wjsc.v13.i7.914.
  • Rangel ÉB, Rodrigues CO, Guimarães-Souza NK. Stem Cell Applications
    in Regenerative Medicine for Kidney Diseases. Stem Cells Int.
    2021;2021:9817324. doi: 10.1155/2021/9817324.
  • Ranjbar A, Hassanzadeh H, Jahandoust F, Miri R, Bidkhori HR, Monzavi
    SM, et al. Allogeneic adipose-derived mesenchymal stromal cell
    transplantation for refractory lupus nephritis: Results of a phase I clinical
    trial. Curr Res Transl Med. 2021;70(2):103324. doi:
    10.1016/j.retram.2021.103324.
  • Shao Z, Meng X, Meng F. Efficacy and safety of mesenchymal stem cell
    in Chinese patients with chronic renal failure: A pilot study in Shandong
    province, China. Pak J Pharm Sci. 2021;34(3(Special)):1227-1231.
  • Carstens MH, García N, Mandayam S, Workeneh B, Pastora I, Calderón
    C, et al. Safety of Stromal Vascular Fraction Cell Therapy for Chronic
    Kidney Disease of Unknown Cause (Mesoamerican Nephropathy). Stem
    Cells Transl Med. 2022:szac080. doi: 10.1093/stcltm/szac080.
  • Wang J, Lin Y, Chen X, Liu Y, Zhou T. Mesenchymal stem cells: A new
    therapeutic tool for chronic kidney disease. Front Cell Dev Biol.
    2022;10:910592. doi: 10.3389/fcell.2022.910592.
  • Xu N, Liu J, Li X. Therapeutic role of mesenchymal stem cells (MSCs) in
    diabetic kidney disease (DKD). Endocr J. 2022. doi:
    10.1507/endocrj.EJ22-0123.
  • Li J, Luo M, Li B, Lou Y, Zhu Y, Bai X, et al. Immunomodulatory Activity
    of Mesenchymal Stem Cells in Lupus Nephritis: Advances and
    Applications. Front Immunol. 2022;13:843192. doi:
    10.3389/fimmu.2022.843192.
  • Morello W, Budelli S, Bernstein DA, Montemurro T, Montelatici E,
    Lavazza C, et al. First clinical application of cord blood mesenchymal
    stromal cells in children with multi-drug resistant nephrotic syndrome.
    Stem Cell Res Ther. 2022;13(1):420. doi: 10.1186/s13287-022-03112-7.
  • Hu Q, Chen Y, Deng X, Li Y, Ma X, Zeng J, et al. Diabetic nephropathy:
    Focusing on pathological signals, clinical treatment, and dietary
    regulation. Biomed Pharmacother. 2023;159:114252. doi:
    10.1016/j.biopha.2023.114252.

GRAFT-VERSUS-HOST DISEASE


  • Colom Díaz PA, Mistry JJ, Trowbridge JJ. Hematopoietic Stem Cell Aging
    and Leukemia Transformation. Blood. 2023. doi:
    10.1182/blood.2022017933.
  • Li Y, Hao J, Hu Z, Yang YG, Zhou Q, Sun L, Wu J. Current status of clinical
    trials assessing mesenchymal stem cell therapy for graft versus host
    disease: a systematic review. Stem Cell Res Ther. 2022;13(1):93. doi:
    10.1186/s13287-022-02751-0.
  • Li R, Tu J, Zhao J, Pan H, Fang L, Shi J. Mesenchymal stromal cells as
    prophylaxis for graft-versus-host disease in haplo-identical
    hematopoietic stem cell transplantation recipients with severe aplastic
    anemia?-a systematic review and meta-analysis. Stem Cell Res Ther.
    2021;12(1):106. doi: 10.1186/s13287-021-02170-7.
  • Yu Q, Wang H, Zhang L, Wei W. Advances in the treatment of
    graft-versus-host disease with immunomodulatory cells. Int
    Immunopharmacol. 2021;92:107349. doi:
    10.1016/j.intimp.2020.107349.
  • Zhang Y, Zheng H, Ren J, Luo X, Zheng Z, Zheng J, et al. Mesenchymal
    stem cells enhance the impact of KIR receptor-ligand mismatching on
    acute graft-versus-host disease following allogeneic hematopoietic stem
    cell transplantation in patients with acute myeloid leukemia but not in
    those with acute lymphocytic leukemia. Hematol Oncol. 2021. doi:
    10.1002/hon.2867.
  • Li T, Luo C, Zhang J, Wei L, Sun W, Xie Q, et al. Efficacy and safety of
    mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell
    transplantation: a systematic review and meta-analysis. Stem Cell Res
    Ther. 2021;12(1):246. doi: 10.1186/s13287-021-02304-x.
  • Bohannon LM, Tang H, Page KM, Ren Y, Jung SH, Artica A, et al.
    Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood
    Transplant vs. Matched Related or Matched Unrelated Donor Transplant
    in Patients with Hematologic Malignancies. Transplant Cell Ther.
    2021:S2666-6367(21)00893-9. doi: 10.1016/j.jtct.2021.05.002.
  • Stenger E, Giver CR, Langston A, Kota D, Das PK, Chinnadurai R, et al.
    Safety of autologous freshly expanded mesenchymal stromal cells for the
    treatment of graft-versus-host disease. Front Immunol.
    2022;13:959658. doi: 10.3389/fimmu.2022.959658.
  • Macías-Sánchez MDM, Morata-Tarifa C, Cuende N, Cardesa-Gil A,
    Cuesta-Casas MÁ, Pascual-Cascon MJ, et al. Mesenchymal Stromal Cells
    for Treating Steroid-Resistant Acute and Chronic Graft Versus Host
    Disease: A Multicenter Compassionate Use Experience. Stem Cells Transl
    Med. 2022:szac003. doi: 10.1093/stcltm/szac003.
  • Zhao K, Lin R, Fan Z, Chen X, Wang Y, Huang F, et al. Mesenchymal
    stromal cells plus basiliximab, calcineurin inhibitor as treatment of
    steroid-resistant acute graft-versus-host disease: a multicenter,
    randomized, phase 3, open-label trial. J Hematol Oncol. 2022;15(1):22.
    doi: 10.1186/s13045-022-01240-4.
  • Shen MZ, Liu XX, Qiu ZY, Xu LP, Zhang XH, Wang Y, et al. Efficacy and
    safety of mesenchymal stem cells treatment for multidrug-resistant
    graft-versus-host disease after haploidentical allogeneic hematopoietic
    stem cell transplantation. Ther Adv Hematol. 2022. doi:
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  • Doglio M, Crossland RE, Alho AC, Penack O, Dickinson AM, Stary G, et
    al. Cell-based therapy in prophylaxis and treatment of chronic
    graft-versus-host disease. Front Immunol. 2022;13:1045168. doi:
    10.3389/fimmu.2022.1045168.
  • Ding Y, Liu C, Cai Y, Hou C, Chen G, Xu Y, et al. The efficiency of human
    umbilical cord mesenchymal stem cells as a salvage treatment for
    steroid-refractory acute graft-versus-host disease. Clin Exp Med. 2023.
    doi: 10.1007/s10238-022-00983-1.
  • Maurer K, Kim HT, Garrity HM, Liney D, Cutler CS, Antin JH, et al. Lower
    Incidence of Chronic GVHD Observed after Transplantation with
    Cryopreserved Unrelated Allogeneic Stem Cells. Blood Adv. 2023. doi:
    10.1182/bloodadvances.2022009231.

AUTOINMUNE AND ALLERGIC DISEASES


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    in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial. BMC Neurol. 2022;22(1):123. doi:
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    and intellectual disability. Stem Cells Dev. 2023. doi: 10.1089/scd.2022.0252.
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AUTISM SPECTRUM DISORDER (AUTISM)


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SPINAL CORD INJURIES


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STROKE


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CENTRAL NERVOUS SYSTEMS (CNS)

TRAUMAS


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    Through Regulating Treg/Th17 Balance. Brain Res. 2021:147711. doi: 10.1016/j.brainres.2021.147711.
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FEMALE INFERTILITY


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    human umbilical cord mesenchymal stem cells to treat premature ovarian
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AGING AND FRAILTY


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SKIN DISORDERS AND ALOPECIA.

AESTHETIC MEDICINE


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EXTRA CELLULAR VESICLES (VEs)


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    vesicles as new tools in regenerative medicine – Immunomodulatory role
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    from Mesenchymal Stem Cells: Towards Novel Therapeutic Strategies for
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    exosomes in the treatment of cardiovascular diseases. J Physiol. 2022.
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